Key result
Physiological maneuvers and diuretics (furosemide, chlorothiazide) produced discrepant changes in plasma versus urinary angiotensin levels, suggesting urinary measurements provide supplementary data.
Why the study?
How do sodium restriction, posture changes, and diuretics affect urinary and plasma angiotensin levels in healthy volunteers?
Population
7 healthy volunteers
Comparison
Sodium restriction, upright posture, intravenous… vs Free sodium intake, supine posture, and baseline…
Authors
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Requires posture- and sodium-controlled sampling for valid angiotensin assays; leaves open standardization in clinical and research protocols.
How do sodium restriction, posture changes, and diuretics affect urinary and plasma angiotensin levels in healthy volunteers?
Discrepancies between changes in plasma and urinary angiotensins suggest that urinary angiotensin excretion provides supplementary physiological information to plasma levels.
Boer et al. (1989) studied Healthy volunteers (n=7). Sodium restriction, upright posture, furosemide, and chlorothiazide vs. Free sodium intake, supine posture, and baseline before diuretics was evaluated on Urinary excretion rate and plasma concentration of angiotensin I and II, and plasma renin activity. Physiological maneuvers and diuretics (furosemide, chlorothiazide) produced discrepant changes in plasma versus urinary angiotensin levels, suggesting urinary measurements provide supplementary data.
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