Key result
Angiotensin II acts via astrocytes to inhibit glutamate transporter function, increasing extracellular glutamate and activating NMDA receptors to enhance sympathoexcitatory outflow.
Population
Preclinical model
Design
Preclinical
Authors
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Suggests astrocytic targets in hypertension; hypothesis-generating and requires human validation.
Astrocytes act as critical intermediary cells mediating brain Angiotensin II regulation of circulation and blood pressure via nonsynaptic glutamate transmission.
Stern et al. (2016) studied Hypertension. Angiotensin II was evaluated on Glutamate transporter function, extracellular glutamate levels, and sympathetic outflow. Angiotensin II acts via astrocytes to inhibit glutamate transporter function, increasing extracellular glutamate and activating NMDA receptors to enhance sympathoexcitatory outflow.
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