Key result
Spontaneously hypertensive rats demonstrated heightened excitability of preinspiratory and postinspiratory neurons relative to Wistar rats, driving excessive sympathetic nerve activity.
Population
Spontaneously hypertensive (SH) rats and Wistar rats (control model)
Comparison
Working heart-brain stem preparation with… vs Wistar rats
Design
Preclinical
Authors
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Identifies potential respiratory neuron targets in rat hypertension models; leaves open translation to human neurogenic hypertension.
Specific respiratory neurons in spontaneously hypertensive rats show increased excitability due to altered potassium conductances, which drives the excessive sympathetic nerve activity characteristic of neurogenic hypertension.
Moraes et al. (2014) studied Neurogenic hypertension. Spontaneous hypertension (SH rats) vs. Wistar rats was evaluated on Respiratory-sympathetic coupling and neuronal excitability. Spontaneously hypertensive rats demonstrated heightened excitability of preinspiratory and postinspiratory neurons relative to Wistar rats, driving excessive sympathetic nerve activity.
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