Key result
Male spontaneously hypertensive rats exhibited greater sensitivity to endothelin-1 and noradrenaline in aortas and mesenteric arterioles, suggesting sex-linked alterations of vascular reactivity.
Sex-linked alterations in vascular reactivity to endothelin-1 and noradrenaline exist in spontaneously hypertensive rats, independent of blood pressure levels.
SHR data suggest sex-specific vascular reactivity but should not change practice; hypothesis-generating for human hypertension research.
The response to endothelin-1 and noradrenaline in isolated aortas in vitro and mesenteric arterioles in situ was studied in male and female spontaneously hypertensive rats (SHR). Greater sensitivity to endothelin-1 and noradrenaline and decreased reactivity to endothelin-1 but not to noradrenaline were found in aortas of male SHR. Mesenteric arterioles of male SHR were more sensitive to endothelin-1 and noradrenaline. Aortas and mesenteric arterioles of female SHR exhibited similar sensitivity to endothelin-1 as compared to controls, whereas a greater reactivity to this agent was only observed in microvessels. It is suggested that sex-linked alterations of vascular reactivity exist in SHR. These alterations seemed not to affect all vascular territories and were not due to differences in blood pressure levels of male and female SHR.
No takes yet. Share an insight, caveat, or question.
Fortes et al. (1991) studied Spontaneously hypertensive rats (SHR). Sex (male vs female) vs. Between sexes and controls was evaluated on Response to endothelin-1 and noradrenaline in isolated aortas in vitro and mesenteric arterioles in situ. Male spontaneously hypertensive rats exhibited greater sensitivity to endothelin-1 and noradrenaline in aortas and mesenteric arterioles, suggesting sex-linked alterations of vascular reactivity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: