Key result
Perivascular adipose tissue in obese mice potentiates vascular contractility to serotonin compared to lean controls (93.8% vs 73.2% KCl, p<0.01) via a cyclooxygenase-derived contracting factor.
Population
Lean controls and mice with either monogenic or diet-induced obesity
Comparison
Assessment of perivascular adipose tissue effect… vs Lean control mice
Design
Preclinical
Authors
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Suggests COX-derived factors as potential targets in obesity hypertension; leaves open translation from murine vessels to human disease.
Absolute Event Rate: 93.8% vs 73.2%
p-value: p=<0.01
Perivascular adipose tissue in obesity releases a COX-derived contracting factor that increases vascular tone, representing a potential mechanism and therapeutic target for obesity-dependent hypertension.
Meyer et al. (2013) studied Obesity. Perivascular adipose tissue in obesity vs. Lean controls was evaluated on Maximal vascular contraction to serotonin (p=<0.01). Perivascular adipose tissue in obese mice potentiates vascular contractility to serotonin compared to lean controls (93.8% vs 73.2% KCl, p<0.01) via a cyclooxygenase-derived contracting factor.
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