Key result
In bovine adrenocortical cells, Angiotensin-II and FGF-2 stimulate MAPK activity, whereas ACTH completely blocks this stimulation (IC50 = 0.01 nM), demonstrating cross-talk between signaling pathways.
Population
Bovine adrenocortical (BAC) cells
Comparison
Hormonal treatments including Angiotensin-II… vs Untreated control cells
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of bovine ACTH-MAPK cross-talk to human adrenal function.
This study demonstrates complex positive and negative hormonal regulation of MAPK activity in bovine adrenocortical cells through cross-talk between inositide, cAMP, and tyrosine kinase pathways.
Chabre et al. (1995) studied this question. Angiotensin-II, Fibroblast growth factor-2, and ACTH was evaluated on Mitogen-activated protein kinase (MAPK) activity. In bovine adrenocortical cells, Angiotensin-II and FGF-2 stimulate MAPK activity, whereas ACTH completely blocks this stimulation (IC50 = 0.01 nM), demonstrating cross-talk between signaling pathways.
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