Key result
Restoration of tropomyosin 1 expression in ras-transformed NIH 3T3 cells suppressed anchorage-independent growth and delayed the onset of tumor growth in athymic mice.
Why the study?
Does restoration of tropomyosin 1 expression suppress neoplastic growth in ras-transformed cells?
Population
NIH 3T3 mouse cells transformed by the ras oncogene, and athymic mice
Comparison
Retrovirally mediated cDNA transfer to restore… vs Untransduced ras-transformed cells
Design
Preclinical
Authors
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Supports tropomyosin 1 restoration in ras models; leaves open translation to human cancer therapy.
Does restoration of tropomyosin 1 expression suppress neoplastic growth in ras-transformed cells?
Restoration of tropomyosin 1 expression in ras-transformed cells suppresses neoplastic growth, suggesting its suppression is a necessary event for tumorigenesis.
Prasad et al. (1993) studied Neoplastic transformation by ras oncogene. Retrovirally mediated cDNA transfer of tropomyosin 1 was evaluated on Anchorage-independent growth capability and onset of tumor growth in athymic mice. Restoration of tropomyosin 1 expression in ras-transformed NIH 3T3 cells suppressed anchorage-independent growth and delayed the onset of tumor growth in athymic mice.
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