Key result
Body weight loss of ≥5% at 6 months after discharge for acute heart failure was associated with increased subsequent all-cause death (14.2% vs 4.3%; HR 2.39, 95% CI 1.01-5.65; P=0.048).
Why the study?
The prognostic implication of weight loss after discharge from acute heart failure remains unclear.
Does weight loss of ≥5% after discharge predict subsequent all-cause death in patients with acute heart failure?
Cohort (n=686)
Does weight loss of ≥5% after discharge predict subsequent all-cause death in patients with acute heart failure?
Hazard Ratio: 2.39 (95% CI 1.01–5.65)
Absolute Event Rate: 14.2% vs 4.3%
p-value: p=0.048
A body weight loss of ≥5% at 6 months post-discharge in acute heart failure patients is a significant independent predictor of subsequent all-cause mortality.
Weight loss ≥5% post-AHF discharge was associated with higher mortality; leaves open whether monitoring or intervention improves outcomes.
BACKGROUNDS: The prognostic implication of weight loss after discharge from acute heart failure (AHF) remains unclear. We sought to investigate the association of weight loss between discharge and 6-month visit with subsequent clinical outcomes in patients with AHF. METHODS: We analyzed 686 patients with AHF in the prospective longitudinal follow-up study derived from the Kyoto Congestive Heart Failure registry, and divided them into 2 groups based on the weight loss at 6-month index visit. We defined the weight loss as ≥ 5% decrease in body weight from discharge to 6-month index visit. RESULTS: There were 90 patients (13.1%) with a weight loss at 6-month visit. Patients in the weight loss group compared with those in the no weight loss group had higher body weight at discharge and lower body weight at 6-mont visit. Patients in the weight loss group had a lower systolic blood pressure, higher brain-type natriuretic peptide, lower serum albumin, lower hemoglobin, higher prevalence of heart failure with reduced ejection fraction at 6-month visit, and a lower prescription rate of inhibitors of renin-angiotensin system than those in the no weight loss group. The cumulative 6-month incidence of all-cause death was significantly higher in the weight loss group than in the no weight loss group (14.2% and 4.3%, log-rank P<0.001). The excess adjusted risk of the weight loss group relative to the no weight loss group remained significant for all-cause death (HR 2.39, 95%CI 1.01-5.65, P = 0.048). CONCLUSION: Body weight loss of ≥5% at 6-month visit after discharge was associated with subsequent all-cause death in patients with AHF.
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Seko et al. (2023) conducted a cohort in Acute heart failure (n=686). Weight loss ≥ 5% from discharge to 6-month visit vs. No weight loss (< 5% decrease) was evaluated on All-cause death (HR 2.39, 95% CI 1.01-5.65, p=0.048). Body weight loss of ≥5% at 6 months after discharge for acute heart failure was associated with increased subsequent all-cause death (14.2% vs 4.3%; HR 2.39, 95% CI 1.01-5.65; P=0.048).
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