Malnutrition increased the risk of all-cause mortality in patients with chronic heart failure compared to patients with non-malnutrition (HR 2.15).
Meta-Analysis (n=12,537)
Does malnutrition increase the risk of all-cause mortality in patients with chronic heart failure?
Malnutrition is highly prevalent (46%) in patients with chronic heart failure and is associated with a more than two-fold increased risk of all-cause mortality.
Hazard Ratio: 2.15 (95% CI 1.89–2.45)
p-value: p=<0.05
OBJECTIVE: Malnutrition has a high occurrence in patients with chronic heart failure (CHF). The prevalence of malnutrition and its impact on all-cause mortality in patients with CHF were assessed using a meta-analysis. METHODS: PubMed, Embase, the Cochrane Library, Web of Science, Medline, CBM, CNKI, WANFANG DATA, and VIP databases were searched to collect cross-sectional and cohort studies on malnutrition, and the prevalence and all-cause mortality of patients with CHF were determined. The time of retrieval was from the database establishment to May 2021. Two researchers independently performed screening of the literature, data extraction and assessed the risk of bias in the included studies. Then Stata 16.0 software was used for meta-analysis. RESULTS: A total of 10 cross-sectional and 21 cohort studies were included, including 12537 patients with CHF. A meta-analysis demonstrated that the total prevalence of malnutrition in patients with heart failure was 46% (95% confidence interval CI: 0.43, 0.49). Compared to patients with non-malnutrition, malnutrition increased the risk of all-cause mortality in patients with CHF (hazard ratio = 2.15, 95% CI 1.89, 2.45, P < 0.05). DISCUSSION: Current evidence suggests that the prevalence of malnutrition is high among patients with CHF. The risk of all-cause mortality in such patients can be increased by malnutrition. Therefore, the risk of malnutrition in patients with CHF should be considered to reduce the occurrence of adverse clinical outcomes.
Lv et al. (Thu,) conducted a meta-analysis in chronic heart failure (n=12,537). Malnutrition vs. Non-malnutrition was evaluated on All-cause mortality (HR 2.15, 95% CI 1.89, 2.45, p=<0.05). Malnutrition increased the risk of all-cause mortality in patients with chronic heart failure compared to patients with non-malnutrition (HR 2.15).