Key result
Slowing of relaxation in fatigued Xenopus fibers is caused by impaired Ca2+ handling and altered cross-bridge kinetics, whereas in mouse fibers it is solely due to altered cross-bridge kinetics.
The mechanisms underlying slowed relaxation in fatigued skeletal muscle differ between species, involving both impaired Ca2+ handling and altered cross-bridge kinetics in Xenopus, but only altered cross-bridge kinetics in mice.
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Species differences in fatigue mechanisms urge caution extrapolating to humans; leaves open Ca2+ handling's role in mammalian muscle.
Westerblad et al. (1997) studied Skeletal muscle fatigue. Fatigue vs. Non-fatigued state was evaluated on Relative contribution of altered Ca2+ handling and cross-bridge component to slowing of relaxation. Slowing of relaxation in fatigued Xenopus fibers is caused by impaired Ca2+ handling and altered cross-bridge kinetics, whereas in mouse fibers it is solely due to altered cross-bridge kinetics.
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