August 1, 2002Journal of Hypertension
The majority of nondipping men do not have increased cardiovascular risk: a population-based study
Key result
Diabetes was more prevalent in nondippers than dippers (26% vs 14%, P<0.05), and nondipping interacted with diabetes to increase left ventricular mass (P<0.05).
Why the study?
Does a nondipping blood pressure pattern associate with increased metabolic risk and target organ damage in 70-year-old men with and without diabetes?
Population
Population-based cohort of 70-year-old men (n = 1057).
Comparison
Nondipping blood pressure pattern. vs Dipping blood pressure pattern.
Design
Cohort
Authors
Discussion
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Implication
Nondipping with diabetes was associated with adverse metabolic profiles and organ damage in elderly men; hypothesis-generating, prospective studies needed before clinical adoption.
Study Design
Type
Cohort (n=1,057)
Structured PICO
Does a nondipping blood pressure pattern associate with increased metabolic risk and target organ damage in 70-year-old men with and without diabetes?
P
Population
1,057 70-year-old men evaluated for the relationship between nondipping blood pressure, diabetes, and metabolic risk profile or target organ damage.
E
Exposure
Nondipping blood pressure pattern (defined as a night-day systolic blood pressure ratio >= 1).
C
Comparator
Dipping blood pressure pattern.
O
Outcome
Metabolic risk profile (insulin sensitivity, plasma glucose, lipids, body mass index) and prevalence of target organ damage (urinary albumin excretion rate and echocardiographically determined left ventricular geometry).surrogate
A nondipping blood pressure pattern is a marker of increased metabolic risk and target organ damage in diabetic men, but not in the nondiabetic majority.
Cite This Study
Björklund et al. (2002) conducted a cohort in Cardiovascular risk (n=1,057). Nondipping blood pressure vs. Dipping blood pressure was evaluated on Metabolic risk profile and target organ damage. Diabetes was more prevalent in nondippers than dippers (26% vs 14%, P<0.05), and nondipping interacted with diabetes to increase left ventricular mass (P<0.05).