Nondipping Pattern and Cardiovascular and Renal Damage in a Population-Based Study (The STANISLAS Cohort Study)
Key result
A nondipping blood pressure pattern was not associated with increased cardiovascular or renal damage in a middle-aged population with overall optimal 24-hour blood pressure control.
Why the study?
The association between a nondipping blood pressure pattern and target organ damage remains debated and poorly studied in normotensive individuals.
Does a nondipping blood pressure pattern associate with increased subclinical cardiovascular and renal damage in a middle-aged population with optimal BP control?
Population
1,334 subjects from the 4th visit of the STANISLAS cohort
Comparison
Nondipper pattern vs dipper pattern
Design
Single-center, familial longitudinal cohort study
Authors
Discussion
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Member takes
Implication
Does not support routine dipping assessment in well-controlled middle-aged adults; leaves open its value in uncontrolled or higher-risk populations.
Study Design
Type
Cohort (n=1,334)
Multicenter
No
Structured PICO
Does a nondipping blood pressure pattern associate with increased subclinical cardiovascular and renal damage in a middle-aged population with optimal BP control?
P
Population
1,334 subjects from the 4th visit of the STANISLAS cohort, including 798 normotensive subjects (mean age 45 ± 14 years) and 536 hypertensive patients (mean age 56 ± 11 years, 19% treated).
I
Intervention
Nondipping blood pressure pattern (defined as a mean reduction in systolic or diastolic BP lower than 10% during nighttime)
C
Comparator
Dipping blood pressure pattern (reduction ≥10% during nighttime)
O
Outcome
Subclinical cardiovascular and renal damage (including estimated glomerular filtration rate, albumin/creatinine ratio, pulse wave velocity, central systolic BP, carotid intima-media thickness and distensibility, left ventricular mass index, left ventricular hypertrophy, and diastolic dysfunction)surrogate
In a middle-aged population with well-controlled blood pressure, a nondipping nocturnal blood pressure pattern is not associated with increased subclinical cardiovascular or renal damage.
Cite This Study
Lopez‐Sublet et al. (2019) conducted a cohort in Normotensive and hypertensive subjects (n=1,334). Nondipping blood pressure pattern vs. Dipping blood pressure pattern was evaluated on Subclinical cardiovascular and renal damage. A nondipping blood pressure pattern was not associated with increased cardiovascular or renal damage in a middle-aged population with overall optimal 24-hour blood pressure control.