What question did this study set out to answer?

To develop cross-sectional reference values for serum insulin-like growth factor I measured by automated chemiluminescence immunoassay.

Serum Insulin-Like Growth Factor I Reference Values for an Automated Chemiluminescence Immunoassay System: Results from a Multicenter Study

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Multicenter study reports reference values for serum IGF-I in healthy individuals, indicating age and sex differences.

To develop cross-sectional reference values for serum insulin-like growth factor I measured by automated chemiluminescence immunoassay.
Included samples from 3,961 healthy subjects aged 1 month to 88 years across six laboratories.
Analyzed S-IGF-I using seven automated immunoassay systems.
Fitted polynomial age and sex-specific models after transforming S-IGF-I values.
S-IGF-I levels showed well-known age dependence, with a peak of 410 microg/l at age 14 in girls and 382 microg/l at age 16 in boys.
A rapid decrease in S-IGF-I levels was observed until approximately 25 years of age, followed by a slow decrease.
Males had slightly higher S-IGF-I levels than females in adulthood.

Brabant et al. (2003) studied this question.

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