Key result
A low level of high-density lipoprotein cholesterol was associated with ischemic heart disease, with the HDL to LDL ratio being ≤0.20 in all affected patients.
Why the study?
Does a low level of high-density lipoprotein cholesterol influence the development of ischemic heart disease in patients with familial hypercholesterolemia?
Population
A large kindred with familial hypercholesterolemia
Design
Cohort
Authors
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Upper-quartile LDL-C identifies nearly all IHD cases in this FH kindred; leaves open generalizability and sex-specific screening implications.
Observational
Does a low level of high-density lipoprotein cholesterol influence the development of ischemic heart disease in patients with familial hypercholesterolemia?
Low levels of high-density lipoprotein cholesterol, alongside high low-density lipoprotein cholesterol, are associated with the development of ischemic heart disease in familial hypercholesterolemia.
Streja et al. (1978) conducted an observational in Familial hypercholesterolemia. Low level of high-density lipoprotein cholesterol vs. Higher levels of high-density lipoprotein cholesterol was evaluated on Ischemic heart disease. A low level of high-density lipoprotein cholesterol was associated with ischemic heart disease, with the HDL to LDL ratio being ≤0.20 in all affected patients.
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