Key result
Genetic factors accounted for 62% of the variation in plasma PAF-AH activity, which was also strongly correlated with plasma LDL-C concentrations.
Why the study?
What are the genetic and environmental determinants of plasma PAF-AH activity, and how does it relate to plasma lipoproteins?
Population
240 individuals from 60 nuclear families, as well as families with well-defined monogenic disorders of LDL…
Design
Cross-sectional
Authors
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Substantial heritability of PAF-AH activity in families; leaves open specific loci and any clinical relevance.
Observational (n=240)
What are the genetic and environmental determinants of plasma PAF-AH activity, and how does it relate to plasma lipoproteins?
Effect estimate: 62% heritability
Plasma PAF-AH activity is highly heritable and strongly correlated with LDL-C levels, suggesting that the rate of LDL removal from circulation may determine PAF-AH clearance.
Guerra et al. (1997) reported an observational. Genetic factors and plasma LDL-C concentrations was evaluated on Variation in plasma PAF-AH activity (62% heritability). Genetic factors accounted for 62% of the variation in plasma PAF-AH activity, which was also strongly correlated with plasma LDL-C concentrations.
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