What question did this study set out to answer?

To determine whether allelic variants in the human PAFAH gene contribute to variability in plasma PAF-acetylhydrolase activity within 72 hours of ARDS diagnosis.

January 19, 2009Journal of Clinical Pharmacy and Therapeutics

Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients andPAFAHgenotype

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Authors

SLS. LiIQVIA (United States)LSL.D. StuartSmithsonian Institution YZY. Zhang

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Implication

Cohort study reveals higher PAF-acetylhydrolase activity linked to Arg92 homozygosity and 7-day survival in ARDS patients, indicating a genetic basis for inflammatory outcomes.

Key Points

To determine whether allelic variants in the human PAFAH gene contribute to variability in plasma PAF-acetylhydrolase activity within 72 hours of ARDS diagnosis.
Measured plasma PAF-acetylhydrolase (PAF-AH) activity in blood samples collected within 72 hours of ARDS diagnosis.
Evaluated PAFAH gene variants (Arg92His, Ile198Thr, and Ala379Val) and tracked 7-day patient survival outcomes (n = 52 evaluated for the Arg92 variant).
Plasma PAF-AH activity was significantly higher in patients homozygous for the Arg92 allele compared to His92 carriers (2.21 ± 0.77 vs. 1.64 ± 0.68 U/min; P < 0.01; n = 31 and 21, respectively).
Baseline plasma PAF-AH activity was significantly higher among day 7 survivors compared to non-survivors (2.05 ± 0.75 vs. 1.27 ± 0.63 U/min; P = 0.05).

Cite This Study

Li et al. (2009) studied this question.

synapsesocial.com/papers/6a9245a1ca631ded64675bf0 https://doi.org/10.1111/j.1365-2710.2008.01014.x

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Implication

Cohort study reveals higher PAF-acetylhydrolase activity linked to Arg92 homozygosity and 7-day survival in ARDS patients, indicating a genetic basis for inflammatory outcomes.

Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients andPAFAHgenotype

Discussion

Member takes

Implication

Key Points

Cite This Study

Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients andPAFAHgenotype

Discussion

Member takes

Implication

Key Points

Cite This Study

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