Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis
Key result
The highest quartile of plasma PAF-AH activity was associated with a 1.8-fold increased risk of coronary artery disease compared with the lowest quartile (OR 1.8; 95% CI 1.01-3.2; P=0.048).
Why the study?
Is higher plasma PAF-AH activity associated with an increased risk of coronary artery disease and inflammatory markers?
Population
973 individuals, comprising 496 patients with coronary artery disease and 477 controls.
Comparison
Highest quartile of plasma platelet-activating… vs First quartile of plasma PAF-AH activity and…
Design
Cross-sectional
Authors
Discussion
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Implication
Higher PAF-AH activity may mark CAD risk independent of inflammation; leaves open whether it is causal or a biomarker.
Study Design
Type
Cross-Sectional (n=973)
Structured PICO
Is higher plasma PAF-AH activity associated with an increased risk of coronary artery disease and inflammatory markers?
P
Population
973 individuals, comprising 496 patients with coronary artery disease and 477 controls, assessed for PAF-AH activity and inflammatory markers.
E
Exposure
Highest quartile of plasma platelet-activating factor-acetylhydrolase (PAF-AH) activity
C
Comparator
First quartile of plasma PAF-AH activity and healthy controls
O
Outcome
Risk/presence of coronary artery disease (CAD)surrogate
Main Result
Odds Ratio: 1.8 (95% CI 1.01–3.2)
p-value: p=0.048
Higher plasma PAF-AH activity is associated with an increased risk of coronary artery disease, particularly in patients not receiving statins or ACE inhibitors, independent of common inflammatory markers.
Cite This Study
Blankenberg et al. (2003) conducted a cross-sectional in Coronary artery disease (n=973). Highest quartile of PAF-AH activity vs. First quartile of PAF-AH activity was evaluated on Coronary artery disease risk (OR 1.8, 95% CI 1.01-3.2, p=0.048). The highest quartile of plasma PAF-AH activity was associated with a 1.8-fold increased risk of coronary artery disease compared with the lowest quartile (OR 1.8; 95% CI 1.01-3.2; P=0.048).