Key result
Patients with coronary artery disease and positive exercise tests had significantly lower resting PAF EC50 values compared to normal subjects (12.6 vs 24.9 nM, P<0.0001).
Why the study?
Does platelet aggregability to PAF differ at rest and after exercise in CAD patients with positive versus negative exercise tests compared to normal subjects?
Population
44 patients with coronary artery disease undergoing exercise tests and 21 normal subjects.
Comparison
Exercise test vs Normal subjects and CAD patients with negative…
Design
Cross-sectional
Authors
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Heightened resting PAF aggregability in CAD with positive tests may increase ischemic risk; leaves open causal links and therapeutic implications.
Observational (n=65)
Does platelet aggregability to PAF differ at rest and after exercise in CAD patients with positive versus negative exercise tests compared to normal subjects?
Absolute Event Rate: 12.6% vs 24.9%
p-value: p=<0.0001
Patients with CAD and inducible ischemia (positive exercise test) exhibit heightened platelet aggregability to PAF at rest compared to normal subjects.
Goudevenos et al. (1995) conducted an observational in Coronary artery disease (n=65). Positive exercise test result vs. Normal subjects was evaluated on PAF EC50 values at rest (nM) (p=<0.0001). Patients with coronary artery disease and positive exercise tests had significantly lower resting PAF EC50 values compared to normal subjects (12.6 vs 24.9 nM, P<0.0001).
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