January 1, 2001European Journal of Clinical Investigation

Platelet‐associated and secreted PAF‐acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty

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Why the study?

Does elective PTCA alter platelet-associated and secreted PAF-AH activity in patients with stable angina?

Population

27 patients with stable angina undergoing elective percutaneous transluminal coronary angioplasty and 30…

Comparison

Elective percutaneous transluminal coronary… vs Age- and sex-matched controls and temporal…

Design

Cohort

Follow-up

6 months

Authors

JGJohn GoudevenosGeneral Cardiology ATAlexandros D. TselepisVascular Medicine MVM.P. ViniInserm

Discussion

Member takes

Implication

PTCA may normalize elevated platelet PAF-AH activity by 6 months in stable angina; leaves open whether this affects outcomes or requires targeted monitoring.

Structured PICO

Does elective PTCA alter platelet-associated and secreted PAF-AH activity in patients with stable angina?

Population

27 patients with stable angina undergoing elective percutaneous transluminal coronary angioplasty (PTCA) and 30 age- and sex-matched controls (total n=57).

Intervention

Elective percutaneous transluminal coronary angioplasty (PTCA)

Comparator

Age- and sex-matched controls (for baseline comparison) and temporal comparison (pre- vs post-PTCA)

Outcome

Platelet-associated and secreted PAF-AH activity measured before PTCA, and at 4 h, 48 h, and 6 months afterwardssurrogate

PTCA in patients with stable angina restores altered platelet PAF-AH activity and platelet hyper-reactivity to PAF by 6 months post-procedure.

Cite This Study

Goudevenos et al. (2001) studied this question.

synapsesocial.com/papers/6a901d41ebb21526730d3438 https://doi.org/10.1046/j.1365-2362.2001.00782.x

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Implication

PTCA may normalize elevated platelet PAF-AH activity by 6 months in stable angina; leaves open whether this affects outcomes or requires targeted monitoring.

Platelet‐associated and secreted PAF‐acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Platelet‐associated and secreted PAF‐acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider