Key result
The aortic valve performs highly sophisticated functions regulated by its cellular parts, allowing adaptation to its hemodynamic and mechanical environment.
Understanding the cellular and molecular mechanisms of normal aortic valve physiology is essential for elucidating the mechanisms behind valve disease.
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Aortic valve exhibits active adaptive functions; extends passive models and leaves open cellular targets for valve disease research.
The aortic valve was long considered a passive structure that opens and closes in response to changes in transvalvular pressure. Recent evidence suggests that the aortic valve performs highly sophisticated functions as a result of its unique microscopic structure. These functions allow it to adapt to its hemodynamic and mechanical environment. Understanding the cellular and molecular mechanisms involved in normal valve physiology is essential to elucidate the mechanisms behind valve disease. We here review the structure and developmental biology of aortic valves; we examine the role of its cellular parts in regulating its function and describe potential pathophysiological and clinical implications.
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El-Hamamsy et al. (2010) conducted a review in Aortic valve physiology and disease. The aortic valve performs highly sophisticated functions regulated by its cellular parts, allowing adaptation to its hemodynamic and mechanical environment.
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