Experimental study demonstrates enantioselective microbial deuteration using novel strains and spectroscopy, highlighting new biocatalytic routes for isotope labelling.
as an affordable carbon source. These findings emphasise the potential of microbial strains not traditionally employed by synthetic organic chemists for isotope labelling. Finally, molecular rotational resonance spectroscopy (MRR) was employed as an analytical tool. MRR was shown to provide accurate measurement of site-specific deuteration levels and enantiopurity, validating its utility for simplifying process evaluation in deuterium-labelling chemistry. This work underscores the value of diverse microbial resources and advanced spectroscopic methods in advancing isotope labelling and biocatalysis, with implications for both research and industrial applications.
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Recsei et al. (2025) studied this question.
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