Key result
Various DNA and RNA viruses encode gene products that antagonize the antiviral functions of host enzymes PKR and ADAR1 through mechanisms including RNA sequestration, direct protein interaction, and subcellular relocalization.
This review highlights the diverse mechanisms by which viral gene products antagonize the antiviral functions of host enzymes PKR and ADAR1.
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PKR and ADAR1 roles in interferon signaling merit further study; leaves open therapeutic targeting in viral diseases.
George et al. (2009) conducted a review in Viral infection. Viral gene products was evaluated. Various DNA and RNA viruses encode gene products that antagonize the antiviral functions of host enzymes PKR and ADAR1 through mechanisms including RNA sequestration, direct protein interaction, and subcellular relocalization.
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