April 14, 2011Journal of VirologyOpen Access

Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase

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Population

RNA viruses and host cell models

Design

Review

Authors

Discussion

ADAR1 inhibition merits exploration as host-directed antiviral strategy; leaves open clinical translation pending prospective validation.

Population

RNA viruses (hepatitis delta virus, human immunodeficiency virus type 1, vesicular stomatitis virus, and measles virus) and host cell models

Intervention

ADAR1 (Adenosine deaminase acting on RNA 1) activity

Outcome

Viral replication

ADAR1, an interferon-induced protein, promotes rather than restricts the replication of several RNA viruses via RNA editing and PKR inhibition.

Gélinas et al. (2011) studied this question.

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