Why the study?
Does ADAR1 increase host susceptibility to vesicular stomatitis virus infection in mouse embryonic fibroblasts?
Population
PKR+/+ and PKR-/- mouse embryonic fibroblasts infected with vesicular stomatitis virus (VSV)
Comparison
ADAR1 vs Absence of ADAR1 or PKR-/- cells
Design
Preclinical
Authors
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ADAR1-PKR interaction may enhance viral susceptibility in fibroblasts; leaves open extension to in vivo pathogenesis or host-directed therapies.
Does ADAR1 increase host susceptibility to vesicular stomatitis virus infection in mouse embryonic fibroblasts?
ADAR1 exhibits a proviral effect by increasing host susceptibility to viral infection through the inhibition of PKR activation, independent of its dsRNA editing function.
Nie et al. (2006) studied this question.
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