August 27, 2009Journal of Biological ChemistryOpen Access

RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR

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Population

Human HeLa cells stably deficient in ADAR1 (ADAR1 cells) and ADAR1-sufficient cells infected with measles…

Comparison

ADAR1 deficiency via short hairpin RNA-mediated… vs ADAR1-sufficient cells

Design

Preclinical

Authors

ATAnn M. TothCraig Hospital ZLZhiqun LiHainan Medical University RCRoberto CattaneoMayo Clinic in Arizona

Discussion

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Implication

ADAR1 may act as proviral factor in measles; leaves open whether its inhibition offers therapeutic benefit in vivo.

Structured PICO

Population

Human HeLa cells stably deficient in ADAR1 (ADAR1(kd) cells) and ADAR1-sufficient cells infected with measles virus (MVvac strain, wild type, V(ko), C(ko))

Intervention

ADAR1 deficiency via short hairpin RNA-mediated knockdown

Comparator

ADAR1-sufficient cells

Outcome

Measles virus growth and virus-induced cell death (apoptosis)surrogate

ADAR1 acts as a proviral, antiapoptotic host factor during measles virus infection by suppressing proapoptotic and double-stranded RNA-dependent activities such as PKR and IRF-3.

Cite This Study

Toth et al. (2009) studied this question.

synapsesocial.com/papers/6a89c85a81d3bfa98ef7dd3b https://doi.org/10.1074/jbc.m109.045146

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RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR

Discussion

Member takes

Implication

Structured PICO

Cite This Study

RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider