Key result
Intravenous propranolol increased myocardial lactate extraction during pacing-induced ischemia in all 10 patients, likely driven by increased glutamate uptake.
Why the study?
Does intravenous propranolol improve myocardial lactate extraction during pacing-induced ischemia in patients with coronary artery disease?
Population
10 patients with chronic effort angina and coronary artery disease
Comparison
Intravenous propranolol administered 15 minutes… vs Baseline measurements before propranolol…
Design
Other
Follow-up
15 minutes after administration
Authors
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No change in coronary flow or O2 consumption after propranolol during pacing; leaves open antianginal mechanisms in CAD.
Does intravenous propranolol improve myocardial lactate extraction during pacing-induced ischemia in patients with coronary artery disease?
Propranolol improves myocardial lactate extraction during pacing-induced ischemia, likely mediated by extracardial metabolic effects including increased glutamate uptake and reduced free fatty acid uptake.
Nielsen et al. (1986) studied Chronic effort angina and coronary artery disease (n=10). Intravenous propranolol vs. Before propranolol (baseline) was evaluated on Myocardial lactate extraction. Intravenous propranolol increased myocardial lactate extraction during pacing-induced ischemia in all 10 patients, likely driven by increased glutamate uptake.
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