What is the clinical evidence from this study?

Study design: Other. Population: Doxorubicin cardiotoxicity. Intervention: Swim training program vs. Sedentary. Primary outcome: Degree of cardiotoxicity and antioxidant enzyme levels.

What question did this study set out to answer?

This study aims to investigate how exercise affects antioxidant enzyme levels and cardiotoxic responses to doxorubicin.

October 1, 1985Journal of Applied Physiology

Effect of exercise training on antioxidant enzymes and cardiotoxicity of doxorubicin

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Key result

A 21-week swim training program ameliorated severe toxic damage caused by doxorubicin administration in mice, with significantly greater cardiotoxicity seen in sedentary drug-treated animals.

Authors

MKM. M. KanterUniversity of Minnesota RHRobert L. HamlinElectrophysiology DUDonald V. UnverferthOhio State University Hospital

Discussion

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Implication

May support exercise modulation of doxorubicin effects in mice; leaves open clinical translation to anthracycline cardioprotection.

Key Points

This study aims to investigate how exercise affects antioxidant enzyme levels and cardiotoxic responses to doxorubicin.
Mice underwent a 21-week swim training program (1 h/day, 5 days/week).
Doxorubicin was administered (4 mg/kg) intravenously over a 7-week period.
Levels of catalase, superoxide dismutase, and glutathione peroxidase were measured in blood and tissues.
After 9 weeks of training, swim-trained mice showed elevated levels of catalase, superoxide dismutase, and glutathione peroxidase.
Sedentary mice treated with doxorubicin experienced significantly greater cardiotoxicity than swim-trained counterparts.
Exercise was correlated with higher antioxidant enzyme levels, suggesting reduced oxidative damage from doxorubicin.

PICO

Population

Mice placed on a 21-week swim training program with and without doxorubicin administration.

Intervention / Comparator

Swim training program vs Sedentary (1 h/day, 5 days/wk)

Primary Outcome

Degree of cardiotoxicity and antioxidant enzyme levels

Cite This Study

Kanter et al. (1985) studied Doxorubicin cardiotoxicity. Swim training program vs. Sedentary was evaluated on Degree of cardiotoxicity and antioxidant enzyme levels. A 21-week swim training program ameliorated severe toxic damage caused by doxorubicin administration in mice, with significantly greater cardiotoxicity seen in sedentary drug-treated animals.

synapsesocial.com/papers/6a6be5cd34b735385cb3d85f https://doi.org/10.1152/jappl.1985.59.4.1298

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Effect of exercise training on antioxidant enzymes and cardiotoxicity of doxorubicin

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Effect of exercise training on antioxidant enzymes and cardiotoxicity of doxorubicin

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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