Key result
Vitamin D deficiency in female adolescents was associated with normal myocardial function but higher carotid intima-media thickness compared to controls, suggesting potential endothelial dysfunction.
Why the study?
The study was conducted to assess left and right ventricle systolic and diastolic functions and investigate carotid intima media thickness and asymmetric dimethylarginine levels in female adolescents with vitamin D deficiency.
Is vitamin D deficiency associated with impaired ventricular function, increased carotid intima media thickness, or altered asymmetric dimethylarginine levels in female adolescents?
Observational (n=66)
Is vitamin D deficiency associated with impaired ventricular function, increased carotid intima media thickness, or altered asymmetric dimethylarginine levels in female adolescents?
Vitamin D deficiency in female adolescents is associated with increased carotid intima-media thickness, suggesting early endothelial dysfunction, despite normal myocardial function.
Vitamin D deficiency may indicate early endothelial changes despite preserved cardiac function in female adolescents; prospective studies needed before clinical implications.
BACKGROUND: The aim of our study was to assess left and right ventricle systolic and diastolic functions in female adolescents with vitamin D deficiency using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotid intima media thickness and asymmetric dimethylarginine levels. METHODS: Sixty-six female adolescents were enrolled in this study. The female adolescents were divided into a vitamin D deficiency group (n: 34) and a control group (n: 32). All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulse, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness. RESULTS: The vitamin D-deficient female adolescent group had normal left and right ventricle systolic and diastolic functions and normal global systolic and diastolic myocardial performance. In the patients with vitamin D deficiency, the carotid intima-media thickness was higher than that in the controls. In the patients within the vitamin D deficiency group, vitamin D was found to be positively correlated with magnesium and negatively correlated with phosphorus and left atrial dimension. CONCLUSIONS: The results of this study demonstrate that vitamin D deficiency in female adolescence is associated with normal myocardial geometry and function. Although it has been associated with normal levels of asymmetric dimethyl arginine concentration, high measured carotid intima-media thickness may reflect endothelial dysfunction.
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Aslan et al. (2023) conducted an observational in Vitamin D deficiency (n=66). Vitamin D deficiency vs. Control group (normal vitamin D) was evaluated on Left and right ventricle systolic and diastolic functions, carotid intima-media thickness, and asymmetric dimethylarginine levels. Vitamin D deficiency in female adolescents was associated with normal myocardial function but higher carotid intima-media thickness compared to controls, suggesting potential endothelial dysfunction.
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