Effects of vitamin D deficiency on left atrial function as evaluated by 2D speckle‐tracking echocardiography

PURPOSE: Vitamin D deficiency is prevalent the world over, and some of its effects on the cardiovascular system have been previously demonstrated. We evaluated left atrial (LA) function via 2D speckle-tracking echocardiography (2DSTE) in subjects with and without vitamin D deficiency. METHODS: Ninety-seven consecutive patients without significant coronary artery disease on selective coronary angiography were incorporated in our study and divided according to their serum level of vitamin D into 2 groups: with and without vitamin D deficiency. RESULTS: The early diastolic strain rate, as a marker of LA conduit function, was increased in patients with vitamin D deficiency (P = .008) and after adjustment for age (P = .046). However, after adjustment for all the confounding factors, vitamin D deficiency showed only a trend to be the independent determinant of LA early diastolic longitudinal strain rate (SRE, P = .065). CONCLUSIONS: Our findings indicated that LA function, as evaluated by 2DSTE, was not different between subjects with and without vitamin D deficiency after adjustment for the confounding factors.