Key result
Vitamin D level was an independent predictor for the development of diastolic dysfunction in patients with acute coronary syndrome (OR 0.942; 95% CI 0.888-0.998; P=0.042).
Why the study?
Vitamin D deficiency is associated with poor cardiovascular prognosis and diastolic dysfunction in stable CAD, but its relationship with diastolic dysfunction in ACS was unestablished.
Are low vitamin D levels associated with impaired diastolic function in patients with acute coronary syndrome?
Cross-Sectional (n=117)
Are low vitamin D levels associated with impaired diastolic function in patients with acute coronary syndrome?
Odds Ratio: 0.942 (95% CI 0.888–0.998)
p-value: p=0.042
Low vitamin D levels are independently associated with echocardiographic signs of diastolic dysfunction in patients with acute coronary syndrome and preserved systolic function.
Low vitamin D associated with diastolic dysfunction in ACS; hypothesis-generating, does not support supplementation.
BACKGROUND: Vitamin D deficiency is a common clinical picture associated with poor cardiovascular prognosis. It is also associated with impaired diastolic dysfunction in stable coronary artery disease. We investigated the relationship between vitamin D levels and diastolic dysfunction in patients with acute coronary syndrome (ACS). METHODS: One hundred seventeen patients with the ACS were enrolled in this cross-sectional study. The diastolic function of the patients was evaluated using echocardiography before discharge. We analyzed the relation between serum levels of 25(OH)D and echocardiographic measures of diastolic dysfunction. RESULTS: IVRT and E/e' were found to be significantly greater in patients with low vitamin D levels (115.48±13.64 vs. 106.88±14.80 ms, P<0.05; 10.19±2.80 vs. 8.1±3.2, P<0.05). When regression tests were performed, it was shown that vitamin D level was a predictor (OR=0.935, 95% CI: 0.886-0.987; P=0.015) and independent risk factor (OR=0.942, 95% CI: 0.888-0.998; P=0.042) for the development of diastolic dysfunction. CONCLUSIONS: We found that low vitamin D levels are associated with impaired diastolic function in patients with ACS with preserved left ventricular systolic function.
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Algül et al. (2024) conducted a cross-sectional in Acute coronary syndrome (ACS) (n=117). Vitamin D level was evaluated on Development of diastolic dysfunction (OR 0.942, 95% CI 0.888-0.998, p=0.042). Vitamin D level was an independent predictor for the development of diastolic dysfunction in patients with acute coronary syndrome (OR 0.942; 95% CI 0.888-0.998; P=0.042).
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