Key result
Serial passage 50 of the IBV Arkansas-type DPI strain was less pathogenic than passage 10 or 25 in day-old chicks, while maintaining at least 80% resistance to homologous virus challenge.
Why the study?
Does serial embryo passage of IBV Ark DPI strain to passage 50 reduce pathogenicity while maintaining immunity in day-old broiler chickens compared to earlier passages?
Population
Day-old maternally immune broiler-type chickens
Comparison
Vaccination with Infectious bronchitis virus… vs Vaccination with virus of passage 10 or 25
Design
Preclinical
Follow-up
6 weeks
Authors
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Attenuated passage 50 Ark DPI may enable safer IBV vaccination in broilers; leaves open field efficacy and optimal use in commercial poultry.
Does serial embryo passage of IBV Ark DPI strain to passage 50 reduce pathogenicity while maintaining immunity in day-old broiler chickens compared to earlier passages?
Serial passage of IBV Ark DPI to passage 50 attenuates pathogenicity while preserving protective immunity in broiler chickens.
Gelb et al. (1983) studied Infectious bronchitis virus (IBV). IBV Arkansas-type DPI strain passage 50 vs. IBV Arkansas-type DPI strain passage 10 or 25 was evaluated on Resistance to homologous virus challenge of the upper respiratory tract. Serial passage 50 of the IBV Arkansas-type DPI strain was less pathogenic than passage 10 or 25 in day-old chicks, while maintaining at least 80% resistance to homologous virus challenge.
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