Key result
Angiotensin II triggered mitochondrial-dependent apoptosis in dopaminergic neurons by facilitating mPTP opening through an AT1 receptor-mediated mechanism.
Population
CATH.a cells (dopaminergic neurons)
Design
Preclinical
Authors
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Supports mPTP role in Ang II dopaminergic apoptosis; leaves open PD therapeutic relevance.
Angiotensin II induces apoptosis in dopaminergic neurons via AT1 receptor-mediated mitochondrial mPTP opening, suggesting a potential role for AT1 antagonists in Parkinson's disease.
Ou et al. (2016) studied Parkinson's disease. Angiotensin II was evaluated on Apoptosis rate, caspase-3 activity, cytochrome c levels, and mPTP opening. Angiotensin II triggered mitochondrial-dependent apoptosis in dopaminergic neurons by facilitating mPTP opening through an AT1 receptor-mediated mechanism.
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