Why the study?
Does ANG II induce apoptosis in human coronary artery endothelial cells, and what is the role of AT1 receptors and PKC activation?
Population
Cultured human coronary artery endothelial cells (HCAEC)
Comparison
Angiotensin II exposure in the presence of… vs Anoxia-reoxygenation and TNF-alpha without ANG…
Design
Preclinical
Authors
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Suggests AT1/PKC inhibition may protect endothelial cells; leaves open translation to human coronary disease.
Does ANG II induce apoptosis in human coronary artery endothelial cells, and what is the role of AT1 receptors and PKC activation?
ANG II induces apoptosis in human coronary artery endothelial cells through an AT1 receptor and PKC-dependent pathway.
Li et al. (1999) studied this question.
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