Key result
Angiotensin II and angiotensinogen induced dose-dependent apoptosis in human and rat alveolar epithelial cells, which was completely abrogated by the ANG II-receptor antagonist saralasin.
Why the study?
Does angiotensin II induce apoptosis in human and rat alveolar epithelial cells?
Does angiotensin II induce apoptosis in human and rat alveolar epithelial cells?
Angiotensin II induces apoptosis in human and rat alveolar epithelial cells via the ANG II receptor, suggesting a role for the renin-angiotensin system in lung cell apoptosis.
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May mediate AEC apoptosis in experimental lung injury; leaves open relevance to human disease.
Wang et al. (1999) studied this question. Angiotensin II (ANG II) was evaluated on Apoptosis. Angiotensin II and angiotensinogen induced dose-dependent apoptosis in human and rat alveolar epithelial cells, which was completely abrogated by the ANG II-receptor antagonist saralasin.
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