Key result
ACE-2 regulates alveolar epithelial cell survival by balancing proapoptotic ANGII and antiapoptotic ANG1-7, which inhibits apoptosis through the Mas receptor.
Population
Mouse lung epithelial cell line MLE-12 and primary cultures of Wistar rat alveolar epithelial cells
Comparison
Manipulation of the ACE-2/ANG1-7/Mas axis using… vs Control cells receiving vehicle or no additives
Design
Preclinical
Follow-up
up to 24 hours in culture
Authors
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The ACE-2/ANG1-7/Mas axis protects alveolar epithelial cells from apoptosis induced by ANGII or bleomycin, highlighting a potential protective mechanism against pulmonary fibrosis.
p-value: p=<0.05
The ACE-2/ANG1-7/Mas axis protects alveolar epithelial cells from apoptosis induced by ANGII or bleomycin, highlighting a potential protective mechanism against pulmonary fibrosis.
Uhal et al. (2011) studied Alveolar epithelial cell apoptosis. ANG1-7 and ACE-2 inhibition vs. Vehicle or bleomycin alone was evaluated on Apoptosis (caspase activation and nuclear fragmentation) and JNK phosphorylation (p=<0.05). ACE-2 regulates alveolar epithelial cell survival by balancing proapoptotic ANGII and antiapoptotic ANG1-7, which inhibits apoptosis through the Mas receptor.
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