Key result
AT1-selective receptor antagonists L-158809 or losartan inhibited ANG II-induced apoptosis in alveolar epithelial cells by 90%, whereas AT2-selective antagonists had no effect.
Why the study?
Does AT1 receptor antagonism prevent ANG II-induced apoptosis in alveolar epithelial cells?
Population
Human lung alveolar epithelial cell-derived carcinoma cell line A549 and primary AEC isolated from Wistar rats
Design
Preclinical
Authors
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AT1 mediates ANG II-induced AEC apoptosis in this rat model; leaves open relevance to human lung injury or therapy.
Does AT1 receptor antagonism prevent ANG II-induced apoptosis in alveolar epithelial cells?
Angiotensin II-induced apoptosis in alveolar epithelial cells is mediated specifically by the AT1 receptor subtype, which can be effectively blocked by AT1 antagonists such as losartan.
Papp et al. (2002) studied Alveolar epithelial cell apoptosis. AT1-selective receptor antagonists (L-158809 or losartan) vs. AT2-selective antagonists (PD-123319 or PD-126055) was evaluated on ANG II-induced apoptosis. AT1-selective receptor antagonists L-158809 or losartan inhibited ANG II-induced apoptosis in alveolar epithelial cells by 90%, whereas AT2-selective antagonists had no effect.
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