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December 4, 2020Frontiers in MedicineOpen Access

Pulmonary hypertension was prevalent in 34.6% of ESRD patients undergoing maintenance dialysis, and was independently associated with increased right atrial diameter (OR 1.236), left atrial diameter, and reduced LVEF.

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Why the study?

The study was conducted to determine the prevalence of pulmonary hypertension and its associated factors among end-stage renal disease patients undergoing maintenance dialysis.

What is the prevalence of pulmonary hypertension and its associated factors among ESRD patients on maintenance dialysis?

Population

491 ESRD patients undergoing maintenance dialysis

Comparison

PH vs non-PH groups

Design

Retrospective study

Key result

Pulmonary hypertension was prevalent in 34.6% of ESRD patients undergoing maintenance dialysis, and was independently associated with increased right atrial diameter (OR 1.236), left atrial diameter, and reduced LVEF.

Authors

YZYing ZhangXDXiaohan DingRRRongsheng Rao

Discussion

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Overview

May inform PH screening considerations in dialysis; leaves open prospective validation of risk factors.

Study Design

Type

Observational (n=491)

Multicenter

No

Structured PICO

What is the prevalence of pulmonary hypertension and its associated factors among ESRD patients on maintenance dialysis?

P
Population
491 patients with end-stage renal disease undergoing maintenance hemodialysis, free of severe cardiopulmonary diseases, evaluated for pulmonary hypertension.
O
Outcome
Prevalence of pulmonary hypertension (PH) and its associated factorssurrogate

Main Result

Odds Ratio: 1.236 (95% CI 1.126–1.357)

p-value: p=<0.001

Pulmonary hypertension is highly prevalent (34.6%) among ESRD patients on maintenance dialysis, with left and right atrial sizes and LVEF being independent associated factors.

Limitations

  • Retrospective design cannot determine causality
  • Did not include other potentially valuable factors such as state of nutrition, chronic inflammation, and history
  • Pre-dialysis-associated parameters were not included

Cite This Study

Zhang et al. (2020) conducted an observational in End-stage renal disease (ESRD) on maintenance dialysis (n=491). Right atrium end-diastolic internal diameter (RA) was evaluated on Pulmonary hypertension (PASP > 35 mmHg) (OR 1.236, 95% CI 1.126-1.357, p=<0.001). Pulmonary hypertension was prevalent in 34.6% of ESRD patients undergoing maintenance dialysis, and was independently associated with increased right atrial diameter (OR 1.236), left atrial diameter, and reduced LVEF.

synapsesocial.com/papers/6a6bf1c878a09e5ab7b3be47https://doi.org/10.3389/fmed.2020.570874
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