Key result
Pulmonary hypertension affects ~33% of peritoneal dialysis patients, with risk linked to hypertensive nephropathy.
Why the study?
The risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis were not well defined.
What are the risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis?
Cohort (n=180)
No
What are the risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis?
p-value: p=<0.05
In patients on maintenance peritoneal dialysis, there is a high incidence of pulmonary hypertension, with internal arteriovenous fistula, CRP, and ejection fraction identified as key risk factors.
Alerts clinicians to screen peritoneal dialysis patients for pulmonary hypertension; leaves open whether hypertensive nephropathy is causal or modifiable.
We investigated the risk factors for pulmonary hypertension (PH) in patients receiving maintenance peritoneal dialysis (MPD). A group of 180 end-stage renal disease patients (124 men and 56 women; mean age: 56.43±8.36) were enrolled in our study, which was conducted between January 2009 and June 2014. All of the patients received MPD treatment in the Dialysis Center of the Second Affiliated Hospital of Soochow University. Clinical data, laboratory indices, and echocardiographic data from these patients were collected, and follow-ups were scheduled bi-monthly. The incidence and relevant risk factors of PH were analyzed. The differences in measurement data were compared by t-test and enumeration data were compared with the χ2 test. Among the 180 patients receiving MPD, 60 were diagnosed with PH. The remaining 120 were regarded as the non-PH group. Significant differences were observed in the clinical data, laboratory indices, and echocardiographic data between the PH and non-PH patients (all P<0.05). Furthermore, hypertensive nephropathy patients on MPD showed a significantly higher incidence of PH compared with non-hypertensive nephropathy patients (P<0.05). Logistic regression analysis showed that the proportion of internal arteriovenous fistula, C-reactive protein levels, and ejection fraction were the highest risk factors for PH in patients receiving MPD. Our study shows that there is a high incidence of PH in patients receiving MPD and hypertensive nephropathy patients have an increased susceptibility to PH.
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Zeng et al. (2016) conducted a cohort in End-stage renal disease receiving maintenance peritoneal dialysis (n=180). Hypertensive nephropathy and clinical risk factors (AV fistula, CRP, ejection fraction) vs. Patients without these risk factors was evaluated on Incidence of pulmonary hypertension (p=<0.05). Among 180 patients receiving maintenance peritoneal dialysis, 33.3% (60/180) were diagnosed with pulmonary hypertension, with hypertensive nephropathy significantly increasing susceptibility (P<0.05).
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