Key result
A brachial-ankle pulse wave velocity of 17.49 m/s or higher was independently associated with a significantly increased odds of silent brain infarct (OR 2.30) compared to lower velocities.
Why the study?
Is increased arterial stiffness measured by baPWV associated with the presence of silent brain infarcts in patients without a history of stroke?
Population
240 consecutive patients with no history of stroke, mean age 69 years
Comparison
Arterial stiffness evaluation using… vs Lower baPWV (<17.49 m/s)
Design
Cohort
Authors
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Higher baPWV was associated with SBI; leaves open whether stiffness assessment aids silent infarct screening.
Cohort (n=240)
Outcome assessor blinded
No
Is increased arterial stiffness measured by baPWV associated with the presence of silent brain infarcts in patients without a history of stroke?
Odds Ratio: 2.3 (95% CI 1.02–5.34)
p-value: p=<0.05
Arterial stiffness measured by baPWV is independently associated with silent brain infarcts, suggesting its utility as a non-invasive marker for subclinical cerebrovascular disease.
Saji et al. (2012) conducted a cohort in Silent brain infarct (n=240). Brachial-ankle pulse wave velocity ≥17.49 m/s vs. Brachial-ankle pulse wave velocity <17.49 m/s was evaluated on Presence of silent brain infarct (SBI) (OR 2.30, 95% CI 1.02-5.34, p=<0.05). A brachial-ankle pulse wave velocity of 17.49 m/s or higher was independently associated with a significantly increased odds of silent brain infarct (OR 2.30) compared to lower velocities.
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