Key result
Warfarin therapy in 23 patients with malignant glial tumors and thromboembolic complications resulted in 1 recurrent pulmonary embolism and no radiographic evidence of intratumoral hemorrhage.
Why the study?
Does anticoagulant therapy safely and effectively treat thromboembolic complications in patients with primary malignant brain tumors?
Population
23 patients with malignant glial neoplasms and thromboembolic complications
Design
Case_series
Follow-up
average 5.8 months
Authors
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Anticoagulation showed low recurrence in this small brain tumor series; hypothesis-generating and requires prospective trials before practice change.
Observational (n=23)
Does anticoagulant therapy safely and effectively treat thromboembolic complications in patients with primary malignant brain tumors?
Oral anticoagulant therapy appears to be a safe and effective means of treating thromboembolic complications in patients with residual malignant glial tumors without causing significant intratumoral hemorrhage.
Altschuler et al. (1990) conducted an observational in Malignant glial neoplasms with thromboembolic complications (n=23). Anticoagulant therapy (warfarin) was evaluated on Recurrent pulmonary embolism and intratumoral hemorrhage. Warfarin therapy in 23 patients with malignant glial tumors and thromboembolic complications resulted in 1 recurrent pulmonary embolism and no radiographic evidence of intratumoral hemorrhage.
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