The Impact of Expansive Arterial Remodeling on Clinical Presentation in Carotid Artery Disease: A Multidetector CT Angiography Study
Key result
Symptomatic patients with ≥50% carotid artery stenosis had a significantly higher expansive remodeling ratio compared to asymptomatic patients (1.64 vs 1.41; P=0.02).
Why the study?
Is expansive carotid artery remodeling associated with cerebral ischemic symptoms in patients with significant carotid stenosis?
Population
108 patients with ≥50% internal carotid artery stenosis evaluated by MDCT angiography, including 37…
Comparison
Symptomatic presentation vs Asymptomatic presentation
Design
Cross-sectional
Authors
Discussion
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Implication
Expansive remodeling was associated with symptoms; hypothesis-generating for vulnerability and requires prospective validation.
Study Design
Type
Cross-Sectional (n=108)
Structured PICO
Is expansive carotid artery remodeling associated with cerebral ischemic symptoms in patients with significant carotid stenosis?
P
Population
108 patients with ≥50% carotid artery stenosis evaluated by MDCT angiography, including 37 symptomatic and 71 asymptomatic individuals.
E
Exposure
Symptomatic presentation (cerebral ischemic symptoms including stroke, TIA, or amaurosis fugax)
C
Comparator
Asymptomatic presentation
O
Outcome
Remodeling ratio (RR) calculated by dividing the outer vessel circumference at the site of greatest stenosis by a normal reference-segment vessel circumferencesurrogate
Main Result
Absolute Event Rate: 1.64% vs 1.41%
p-value: p=.02
Expansive carotid remodeling assessed by MDCT is significantly greater in symptomatic patients with significant internal carotid artery stenosis compared to asymptomatic patients, suggesting a link to plaque vulnerability.
Cite This Study
Hardie et al. (2007) conducted a cross-sectional in Carotid artery disease with ≥50% stenosis (n=108). Symptomatic presentation (cerebral ischemic symptoms) vs. Asymptomatic presentation was evaluated on Remodeling ratio (RR) (p=.02). Symptomatic patients with ≥50% carotid artery stenosis had a significantly higher expansive remodeling ratio compared to asymptomatic patients (1.64 vs 1.41; P=0.02).