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July 16, 2002Circulation

β 2 -Adrenergic Receptor Gene Delivery to the Endothelium Corrects Impaired Adrenergic Vasorelaxation in Hypertension

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Key result

Adenoviral-mediated gene transfer of beta2-adrenergic receptors (2-fold overexpression) enhanced betaAR vasorelaxation in spontaneously hypertensive rats to levels seen in normotensive rats.

Why the study?

Does adenoviral-mediated gene transfer of beta2-adrenergic receptors improve betaAR-mediated vasorelaxation in spontaneously hypertensive rats?

Population

Normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats

Comparison

Adenoviral-mediated gene transfer of… vs Empty vector (ADempty)

Design

Preclinical

Follow-up

3 days

Authors

GIGuido IaccarinoHeart Failure & TransplantECErsilia CipollettaAeromechs (Italy)AFAntonia FiorilloDuke University

Discussion

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Implication

Supports endothelial beta(2)AR overexpression to restore vasorelaxation in hypertensive rat arteries; leaves open translation to human hypertension.

Structured PICO

Does adenoviral-mediated gene transfer of beta2-adrenergic receptors improve betaAR-mediated vasorelaxation in spontaneously hypertensive rats?

P
Population
Normotensive Wistar-Kyoto and spontaneously hypertensive rats evaluated for beta2-adrenergic receptor gene delivery to the carotid artery endothelium.
I
Intervention
Adenoviral-mediated gene transfer of beta2-adrenergic receptors (ADbeta2AR) to the vascular endothelium of the carotid artery in situ for 15 minutes
C
Comparator
Empty vector (ADempty)
O
Outcome
betaAR-mediated vasorelaxationsurrogate

Overexpression of beta2-adrenergic receptors in the vascular endothelium corrects impaired vasorelaxation in hypertensive rats, highlighting the endothelium's critical role in betaAR signaling.

Cite This Study

Iaccarino et al. (2002) studied Hypertension. Adenoviral-mediated gene transfer of beta2-adrenergic receptors (ADbeta2AR) vs. Empty vector (ADempty) was evaluated on betaAR-mediated vasorelaxation. Adenoviral-mediated gene transfer of beta2-adrenergic receptors (2-fold overexpression) enhanced betaAR vasorelaxation in spontaneously hypertensive rats to levels seen in normotensive rats.

synapsesocial.com/papers/6a6c0c9c47a1bfb288f36216https://doi.org/10.1161/01.cir.0000022690.55143.56

Topics

Hypertension management
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Also Consider

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