Key result
Targeted modification of extracellular vesicles enhances their stability, biological activity, and target-binding capacity for the treatment of cardiovascular diseases.
Why the study?
The clinical application of native extracellular vesicles for cardiovascular diseases is constrained by their poor stabilities and limited targeting capabilities.
This review highlights the potential of targeted extracellular vesicle therapies, modified via various engineering techniques, to overcome stability and targeting limitations in treating cardiovascular diseases.
EV engineering addresses stability and targeting limits for cardiovascular use; leaves open clinical validation.
Extracellular vesicles (EVs) have emerged as novel diagnostic and therapeutic approaches for cardiovascular diseases. EVs derived from various origins exhibit distinct effects on the cardiovascular system. However, the application of native EVs is constrained due to their poor stabilities and limited targeting capabilities. Currently, targeted modification of EVs primarily involves genetic engineering, chemical modification (covalent, non-covalent), cell membrane modification, and biomaterial encapsulation. These techniques enhance the stability, biological activity, target-binding capacity, and controlled release of EVs at specific cells and tissues. The diverse origins of cardioprotective EVs are covered, and the applications of cardiac-targeting EV delivery systems in protecting against cardiovascular diseases are discussed. This review summarizes the current stage of research on the potential of EV-based targeted therapies for addressing cardiovascular disorders.
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Jiang et al. (2023) conducted a review in Cardiovascular diseases. Targeted extracellular vesicle therapies was evaluated. Targeted modification of extracellular vesicles enhances their stability, biological activity, and target-binding capacity for the treatment of cardiovascular diseases.
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