Key result
Physical activity was found to be a protective factor against cognitive decline in cognitively healthy APOE e4 carriers in four out of five included longitudinal studies.
Why the study?
Physical activity reduces cognitive decline risk in the general population, but whether the apolipoprotein E epsilon 4 allele modifies this effect is unclear.
Does physical activity reduce the risk of cognitive decline in cognitively healthy APOE e4 carriers?
Systematic Review
Does physical activity reduce the risk of cognitive decline in cognitively healthy APOE e4 carriers?
Physical activity appears to protect against cognitive decline in cognitively healthy APOE e4 carriers, with potentially greater benefits at higher amounts and intensities.
May support physical activity counseling in APOE e4 carriers; leaves open confirmation of causality and dosing by RCTs.
Physical activity (PA) reduces the risk of cognitive decline (CD) in the general population. However, little is known about whether the presence of the apolipoprotein E epsilon 4 allele (APOE e4) could modify this beneficial effect. The aim of this systematic review was to analyze and synthetize the scientific evidence related to PA levels and CD risk in cognitively healthy APOE e4 carriers. Four electronic databases were analyzed. Only original articles with longitudinal study design were selected to analyze the relationship between PA and CD in APOE e4 carriers. Five studies were included in the systematic review. All studies except one stated that PA is a protective factor against CD in APOE e4 carriers. Moreover, partial support was found for the hypothesis that a greater amount and intensity of PA are more beneficial in CD prevention. The results support the idea that PA is a protective factor against CD in APOE e4 carriers. Nevertheless, it would be necessary to carry out further studies that would allow these findings to be contrasted.
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Pérez-Lasierra et al. (2021) conducted a systematic review in Cognitive decline in APOE e4 carriers. Physical activity vs. Lower levels of physical activity was evaluated on Cognitive decline. Physical activity was found to be a protective factor against cognitive decline in cognitively healthy APOE e4 carriers in four out of five included longitudinal studies.
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