Key result
Pressure overload caused cardiac insulin resistance and elevated PTP1B activity at 10 and 20 weeks, preceding mitochondrial and systolic dysfunction in rats, with elevated PTP1B also seen in humans.
Population
Rats undergoing aortic banding to induce pressure overload, and human patients with systolic dysfunction…
Design
Preclinical
Follow-up
up to 20 weeks
Authors
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PTP1B inhibition merits testing as HF therapy; animal data leave open translation to human pressure-overload outcomes.
Cardiac insulin resistance and elevated PTP1B activity precede mitochondrial and contractile dysfunction in pressure-overloaded hearts, identifying PTP1B as a potential therapeutic target for heart failure.
Nguyễn et al. (2018) studied Pressure overload-induced heart failure. Pressure overload (aortic banding) was evaluated on Cardiac insulin response and mitochondrial function. Pressure overload caused cardiac insulin resistance and elevated PTP1B activity at 10 and 20 weeks, preceding mitochondrial and systolic dysfunction in rats, with elevated PTP1B also seen in humans.
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