Key result
A discontinuous cardiac cable model demonstrated two effective time constants of activation, establishing a rapid voltage gradient across each cell that reaches a maximum in approximately 3 microseconds.
Cellular discontinuities in a cardiac cable model create rapid voltage gradients across individual cells during transient subthreshold responses, which may play a role in the mechanism of defibrillation.
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Transient cable modeling may refine defibrillation timing assumptions; leaves open steady-state applicability in vivo.
Cartee et al. (1992) studied this question. One-dimensional cardiac model with cellular discontinuities was evaluated on Transient, subthreshold behavior of a discontinuous cardiac cable. A discontinuous cardiac cable model demonstrated two effective time constants of activation, establishing a rapid voltage gradient across each cell that reaches a maximum in approximately 3 microseconds.
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