Key result
Normal ionic BDM solution better preserved left ventricular pressure (-38% vs -72% to -80%) and basal coronary flow after prolonged cold perfusion compared to cold control, high KCl, and low CaCl2.
Why the study?
Does butanedione monoxime improve cardiac function and coronary flow in isolated guinea pig hearts after prolonged hypothermic perfusion compared to high potassium or low calcium solutions?
Does butanedione monoxime improve cardiac function and coronary flow in isolated guinea pig hearts after prolonged hypothermic perfusion compared to high potassium or low calcium solutions?
Normal ionic BDM solution better preserves cardiac function and basal coronary flow after prolonged cold perfusion than high KCl or low CaCl2 solutions in isolated guinea pig hearts.
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No immediate change to clinical preservation protocols; leaves open translation of BDM benefits to human transplantation.
Stowe et al. (1994) studied Cardiac preservation (n=70). Butanedione monoxime (BDM) perfusate vs. High potassium (KCl), low calcium (CaCl2), cold control, and time control solutions was evaluated on Left ventricular pressure (LVP) during warm reperfusion. Normal ionic BDM solution better preserved left ventricular pressure (-38% vs -72% to -80%) and basal coronary flow after prolonged cold perfusion compared to cold control, high KCl, and low CaCl2.
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