January 1, 1994European Journal of Cardio-Thoracic Surgery

Reversible desensitization of the myocardial contractile apparatus for calcium *1A new concept for improving tolerance to cold ischemia in human myocardium?

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Why the study?

Does 2,3-Butanedione monoxime (BDM) improve tolerance to cold ischemia in isolated human myocardial muscle fibers?

Population

Left ventricular human muscle fibers from recipient hearts and right atrial fibers from patients operated…

Comparison

2,3-Butanedione monoxime at concentrations… vs 37°C oxygenated Krebs-Henseleit solution and 4°C…

Design

Preclinical

Authors

CVChristian‐Friedrich VahlJohannes Gutenberg University Mainz ABAndreas BonzKlinikum Lüneburg CHChristian HaglCardiac Surgery

Discussion

Member takes

Implication

Should not yet change preservation practices; hypothesis-generating for BDM in human myocardial cold ischemia tolerance.

Structured PICO

Does 2,3-Butanedione monoxime (BDM) improve tolerance to cold ischemia in isolated human myocardial muscle fibers?

Population

Left ventricular human muscle fibers from recipient hearts (n=10) and right atrial fibers from patients operated upon for aortic valve stenosis or combined mitral valve disease (n=14).

Intervention

2,3-Butanedione monoxime (BDM) at concentrations ranging from 0 to 30 mM, and 4°C Krebs-Henseleit solution containing 30 mM BDM.

Comparator

37°C oxygenated Krebs-Henseleit solution (KHS) and 4°C Bretschneider's cardioplegic solution (HTK) without oxygenation.

Outcome

Intracellular calcium transients and isometric force development.surrogate

BDM reversibly desensitizes the myocardial contractile apparatus to calcium, reducing isometric force development in a dose-dependent manner, which may offer a new concept for improving tolerance to cold ischemia in human myocardium.

Cite This Study

Vahl et al. (1994) studied this question.

synapsesocial.com/papers/6a858e567fcf0fdb395e2397 https://doi.org/10.1016/1010-7940(94)90031-0

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Reversible desensitization of the myocardial contractile apparatus for calcium *1A new concept for improving tolerance to cold ischemia in human myocardium?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reversible desensitization of the myocardial contractile apparatus for calcium *1A new concept for improving tolerance to cold ischemia in human myocardium?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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