Key result
Mutagenesis of the arterivirus Nsp4 protease confirmed it utilizes a canonical His-Asp-Ser catalytic triad and functions as a novel 3C-like serine protease.
Population
Equine arteritis virus (arterivirus) replicase proteins and Nsp4 protease
Comparison
Mutagenesis of predicted catalytic triad and… vs Wild-type Nsp4 protease
Design
Preclinical
Authors
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Does not inform clinical practice; extends classification of 3C-like serine proteases in arteriviruses.
The study characterizes the arterivirus Nsp4 protease as a prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases.
Snijder et al. (1996) studied this question. Mutagenesis of Nsp4 protease was evaluated on Protease catalytic activity and substrate recognition. Mutagenesis of the arterivirus Nsp4 protease confirmed it utilizes a canonical His-Asp-Ser catalytic triad and functions as a novel 3C-like serine protease.
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