Key result
TGF-beta1 suppressed IL-1beta-induced nitric-oxide synthase promoter/enhancer activity in vascular smooth muscle cells through a site other than the NF-kappaB motif.
Population
Primary cultured rat aortic smooth muscle cells transfected with reporter plasmids containing various…
Comparison
Stimulation with IL-1beta and/or TGF-beta1 vs Vehicle or constructs with mutated NF-kappaB site
Design
Preclinical
Authors
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Does not support clinical NO modulation changes; leaves open translation of rat cell transcription data to human disease.
TGF-beta1 suppresses IL-1beta-induced NOS promoter activity in vascular smooth muscle cells via mechanisms independent of the NF-kappaB motif.
Perrella et al. (1996) studied this question. Transforming growth factor-beta1 (TGF-beta1) vs. Vehicle was evaluated on Inducible NOS promoter/enhancer activity. TGF-beta1 suppressed IL-1beta-induced nitric-oxide synthase promoter/enhancer activity in vascular smooth muscle cells through a site other than the NF-kappaB motif.
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